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Mar 9, 2022

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Gene ID Conversion

Introduction


When you combine datasets, run downstream analyses, or visualize results, you almost always need your genes in a single, consistent identifier system (e.g., Ensembl IDs or Entrez IDs). Unfortunately, public resources and pipelines use many different “names” for the same gene: Ensembl stable IDs, Entrez Gene IDs, HGNC symbols, UniProt accessions, microarray probe IDs, etc.


g:Profiler (g:Convert) solves this by providing a central, regularly updated service that translates gene identifiers across dozens of namespaces for hundreds of organisms. The task below wraps g:Convert to give you a simple, reproducible way to normalize your IDs from a table.



🧰 Prerequisites


  • Access to Constellab and a valid Digital Lab environment
    • Installed bricks: gws_omix ≥ 0.13.0
      • Differentially expressed genes file (csv or tsv) , a list of gene symbols, Ensembl IDs, Entrez IDs, UniProt accessions


        🧪 Workflow: Step by Step


        1. Add the required task : Gene_ID_conversion

                              This task performs identifier harmonization on a user-provided list of gene IDs. It uses the g:Profiler g:Convert service to translate input identifiers (e.g., gene symbols, Ensembl IDs, Entrez IDs, UniProt accessions) into a selected target namespace. Unlike manual mapping or static resources, g:Convert queries a continuously updated central database, ensuring that results reflect the latest stable identifiers and gene annotations.  


                   2.   Configurer the task: please read carefully the documentation


                    3.    run task




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